Preview

Офтальмохирургия

Расширенный поиск

ЦИТОКИНЫ И ФАКТОРЫ РОСТА В ПАТОГЕНЕЗЕ ПРОЛИФЕРАТИВНОЙ ДИАБЕТИЧЕСКОЙ РЕТИНОПАТИИ

https://doi.org/10.25276/0235-4160-2017-1-93-97

Полный текст:

Аннотация

В обзоре представлены данные современной научной литературы, касающиеся роли различных классов цитокинов и факторов роста в патогенезе пролиферативной диабетической ретинопатии. Данные о роли в патогенезе ПДР биологически активных молекул, участвующих в воспалительных и ангио-пролиферативных процессах, являются базой для выбора потенциальных молекулярных мишеней для создания новых биоинженерных препаратов.

Об авторах

А. Н. Трунов
ФГАУ «МНТК «Микрохирургия глаза» имени академика С.Н. Федорова» Минздрава России, Новосибирский филиал; ФГБНУ НИИ экспериментальной и клинической медицины
Россия

Трунов Александр Николаевич - доктор медицинских наук, профессор,  заместитель директора по научной работе НФ МНТК «Микрохирургия глаза» имени акад. С.Н. Федорова», руководитель лаборатории иммунологии  НИИ ЭКМ.

Новосибирск, e-mail: trunov1963@yandex.ru



Д. В. Черных
ФГАУ «МНТК «Микрохирургия глаза» имени академика С.Н. Федорова» Минздрава России, Новосибирский филиал
Россия


А. В. Еремина
ФГАУ «МНТК «Микрохирургия глаза» имени академика С.Н. Федорова» Минздрава России, Новосибирский филиал
Россия


В. В. Черных
ФГАУ «МНТК «Микрохирургия глаза» имени академика С.Н. Федорова» Минздрава России, Новосибирский филиал
Россия


Список литературы

1. Черных В.В., Варваринский Е.В., Горбенко О.М. и др. Активность местного воспалительного и пролиферативного процесса в патогенезе диабетической ретинопатии // Бюлл. СО РАМН. – 2013. – Т. 33, № 5. – С. 60-63.

2. Черных Д.В., Смирнов Е.В., Горбенко О.М. и др. Нарушения цитокиновой регуляции в патогенезе пролиферативной диабетической ретинопатии // Офтальмохирургия. – 2015. – № 2. – С. 50-55.

3. Afzal N., Zaman S., Shahzad F. et al. Immune mechanisms in type-2 diabetic retinopathy // J. Pak. Med. Assoc. – 2015. – Vol. 65, № 2. – P. 159-163.

4. Bromberg-White J.L., Glazer L., Downer R. et al. Identification of VEGF-independent cytokines in proliferative diabetic retinopathy vitreous // Invest. Ophthalmol. Vis. Sci. – 2013. – Vol. 54. – P. 6472-6480.

5. Chen H., Wen F., Zhang X., Su S.B. Expression of T-helper-associated cytokines in patients with type 2 diabetes mellitus with retinopathy // Mol. Vis. – 2012. – Vol. 18. – P. 219-226.

6. Chernykh V.V., Varvarinsky E.V., Smirnov E.V. et al. Proliferative and inflammatory factors in the vitreous of patients with proliferative diabetic retinopathy // Ind. J. Ophthalmol. – 2015. – Vol. 63, № 1. – Р. 19-22.

7. Cheung C.M., Vania M., Ang M. et al. Comparison of aqueous humor cytokine and chemokine levels in diabetic patients with and without retinopathy // Mol. Vis. – 2012. – Vol. 18. – P. 830-837.

8. Cheung N., Wong I.Y., Wong T.Y. Ocular antiVEGF therapy for diabetic retinopathy: overview of clinical efficacy and evolving applications // Diabetes Care. – 2014. – Vol. 37, № 4. – Р. 900-905.

9. Citirik M., Kabatas E.U., Batman C. et al. Vitreous vascular endothelial growth factor concentrations in proliferative diabetic retinopathy versus proliferative vitreoretinopathy // Ophthalmic Res. – 2012. – Vol. 47, № 1. – P. 7-12.

10. Costagliola C., Romano V., De Tollis M. et al. TNFalpha levels in tears: a novel biomarker to assess the degree of diabetic retinopathy // Mediators Inflamm. – 2013. – Vol. 2013. – P. 629529.

11. Demircan N., Safran B.G., Soylu M. et al. Determination of vitreous interleukin-1 (IL-1) and tumour necrosis factor (TNF) levels in proliferative diabetic retinopathy // Eye. – 2006. – Vol. 20, № 12. – P. 1366-1369.

12. Dong N., Xu B., Wang B., Chu L. Study of 27 aqueous humor cytokines in patients with type 2 diabetes with or without retinopathy // Mol. Vis. – 2013. – Vol. 19. – P. 1734-1746.

13. Giet M.V., Henkel C., Schuchardt M., Tölle M. Anti-VEGF Drugs in Eye Diseases: Local Therapy with Potential Systemic Effects // Curr. Pharm. Des. – 2015. – Vol. 21. – P. 1-9.

14. Goede V., Brogelli L., Ziche M., Augustin H.G. Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1 // Int. J. Cancer. – 1999. – Vol. 82, № 5. – P. 765-770.

15. Grigsby J., Betts B., Vidro-Kotchan E. et al. A possible role of acrolein in diabetic retinopathy: involvement of a VEGF/TGFβ signaling pathway of the retinal pigment epithelium in hyperglycemia // Curr. Eye Res. – 2012. – Vol. 37, № 11. – P. 1045-1053.

16. Guex-Crosier Y., Behar-Cohen F. Diabetic retinopathy: new therapeutic Possibilities // Rev. Med. Suisse. – 2015. – Vol. 11. – P.101-107.

17. Gustavsson C., Agardh C.D., Agardh E. Profile of intraocular tumour necrosis factor-α and interleukin-6 in diabetic subjects with different degrees of diabetic retinopathy // Acta Ophthalmol. – 2013. – Vol. 91, № 5. – P. 445-452.

18. Hang H., Yuan S., Yang Q. et al. Multiplex bead array assay of plasma cytokines in type 2 diabetes mellitus with diabetic retinopathy // Mol Vis. – 2014. – Vol. 20. – P. 1137-1145.

19. Hernández-Da Mota S.E., Soto-Bahena J.J., Viveros-Sandoval M.E., Cardiel-Ríos M. Pro-inflammatory serum cytokines in diabetic retinopathy // Cir. Cir. – 2015. – Vol. 83, № 2. – Р. 100-106.

20. Huang H., Gandhi J.K., Zhong X. et al. TNFalpha is required for late BRB breakdown in diabetic retinopathy, and its inhibition prevents leukostasis and protects vessels and neurons from apoptosis // Invest. Ophthalmol. Vis. Sci. 2011. – Vol. 52, № 3. – P. 336-344.

21. Johnsen-Soriano S., Sancho-Tello M., Arnal E. et al. IL-2 and IFN-gamma in the retina of diabetic rats // Graefes Arch. Clin. Exp. Ophthalmol. – 2010. – Vol. 248, № 7. – P. 985-990.

22. Joussen A.M., Doehmen S., Le M.L. et al. TNFalpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and longterm histopathological alterations // Mol. Vis. – 2009. – Vol. 15. – P. 1418-1428.

23. Kajdaniuk D., Marek B., Borgiel-Marek H., KosKudła B. Transforming growth factor â1 (TGFâ1) in physiology and pathology // Endokrynol. Pol. – 2013. – Vol. 64, № 5. – Р. 384-396.

24. Kanellakis P., Ditiatkovski M., Kostolias G., Bobik A. A pro-fibrotic role for interleukin-4 in cardiac pressure overload // Cardiovasc. Res. – 2012. – Vol. 95, № 1. – P. 77-85.

25. Kang M.H., Kim M.K., Lee H.J. et al. Interleukin-17 in various ocular surface inflammatory diseases // J. Korean Med. Sci. – 2011. – Vol. 26, № 7. – P. 938-944.

26. Klaassen I., van Geest R.J., Kuiper E.J. et al. The role of CTGF in diabetic retinopathy // Exp. Eye Res. – 2015. – Vol. 133. – P. 37-48.

27. Kocak N., Alacacioglu I., Kaynak S. et al. Comparison of vitreous and plasma levels of vascular endothelial growth factor, interleukin-6 and hepatocyte growth factor in diabetic and non-diabetic retinal detachment cases // Ann. Ophthalmol. – 2010. – Vol. 42. – P. 10-14.

28. Koleva-Georgieva D.N., Sivkova N.P., Terzieva D. Serum inflammatory cytokines IL-1beta, IL-6, TNFalpha and VEGF have influence on the development of diabetic retinopathy // Folia Med. – 2011. – Vol. 53, № 2. – P. 44-50.

29. Li S., Fu X.A., Zhou X.F. et al. Angiogenesisrelated cytokines in serum of proliferative diabetic retinopathy patients before and after vitrectomy // Int. J. Ophthalmol. – 2012. – Vol. 5, № 6. – P. 726-730.

30. Liu Y., Biarnés Costa M., Gerhardinger C. IL-1β is upregulated in the diabetic retina and retinal vessels: cell-specific effect of high glucose and IL-1β autostimulation // PLoS One. – 2012. – Vol. 7, № 5. – Р. 36949.

31. Loukovaara S., Robciuc A., Holopainen J.M. et al. Ang-2 upregulation correlates with increased levels of MMP-9, VEGF, EPO and TGFβ1 in diabetic eyes undergoing vitrectomy // Acta Ophthalmol. – 2013. – Vol. 91, № 6. – P. 531-539.

32. Mao C., Yan H. Roles of elevated intravitreal IL-1β and IL-10 levels in proliferative diabetic retinopathy // Indian J. Ophthalmol. – 2014. – Vol. 62, № 6. – P. 699-701.

33. McAuley A.K., Sanfilippo P.G., Hewitt A.W. et al. Vitreous biomarkers in diabetic retinopathy: a systematic review and meta-analysis // J. Diabetes Complications. – 2014. – Vol. 28, № 3. – P. 419-425.

34. Mocan M.C., Kadayifcilar S., Eldem B. Elevated intravitreal interleukin-6 levels in patients with proliferative diabetic retinopathy // Can. J. Ophthalmol. – 2006. – Vol. 41, № 6. – P. 747-752.

35. Mohan N., Monickaraj F., Balasubramanyam M. et al. Imbalanced levels of angiogenic and angiostatic factors in vitreous, plasma and postmortem retinal tissue of patients with proliferative diabetic retinopathy // J. Diabetes Complications. – 2012. – Vol. 26. – P. 435-441.

36. Murugeswari P., Shukla D., Rajendran A. et al. Proinflammatory cytokines and angiogenic and anti-angiogenic factors in vitreous of patients with proliferative diabetic retinopathy and eales’ disease // Retina. – 2008. – Vol. 28, № 6. – P. 817-824.

37. Myśliwiec M., Balcerska A., Zorena K. et al. The role of vascular endothelial growth factor, tumor necrosis factor alpha and interleukin-6 in pathogenesis of diabetic retinopathy // Diabetes Res. Clin. Pract. – 2008. – Vol. 79, № 1. – P. 141-146.

38. Nadeem A., Javaid K., Sami W. et al. Inverse relationship of serum IL-17 with type-II diabetes retinopathy // Clin. Lab. – 2013. – Vol. 59, № 11-12. – P. 1311-1317.

39. Neurath M.F., Finotto S. IL-6 signaling in autoimmunity, chronic inflammation and inflammationassociated cancer // Cytokine Growth Factor Rev. – 2011. – Vol. 22, № 2. – P. 83-89.

40. Nicholson B.P., Schachat A.P. A review of clinical trials of anti-VEGF agents for diabetic retinopathy // Graefes. Arch. Clin. Exp. Ophthalmol. – 2010. – Vol. 248, № 7. – Р. 915-930.

41. Oh I.K., Kim S.W., Oh J. et al. Inflammatory and angiogenic factors in the aqueous humor and the relationship to diabetic retinopathy // Curr. Eye Res. – 2010. – Vol. 35, № 12. – P. 1116-1127.

42. Palenski T.L., Sorenson C.M., Sheibani N. Inflammatory cytokine-specific alterations in retinal endothelial cell function // Microvasc. Res. – 2013. – Vol. 89. – P. 57-69.

43. Petrovič M.G., Korošec P., Košnik M., Hawlina M. Association of preoperative vitreous IL-8 and VEGF levels with visual acuity after vitrectomy in proliferative diabetic retinopathy // Acta Ophthalmol. – 2010. – Vol. 88, № 8. – P. 311-316.

44. Poniatowski Ł., Wojdasiewicz P., Gasik R., Szukiewicz D. Transforming growth factor Beta family: insight into the role of growth factors in regulation of fracture healing biology and potential clinical applications // Mediators Inflamm. 2015. – Vol. 2015. – P. 137823.

45. Postlethwaite A.E., Holness M.A., Katai H., Raghow R. Human fibroblasts synthesize elevated levels of extracellular matrix proteins in response to interleukin 4 // J. Clin. Invest. – 1992. – Vol. 90, № 4. – P. 1479-1485.

46. Regan D.P., Aarnio M.C., Davis W.S. et al. Characterization of cytokines associated with Th17 cells in the eyes of horses with recurrent uveitis // Vet. Ophtalmol. – 2012. – Vol. 15, № 3. – P. 145-152.

47. Salcedo R., Ponce M.L., Young H.A. et al. Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progression // Blood. – 2000. – Vol. 96, № 1. – P. 34-40.

48. Semeran K., Pawłowski P., Lisowski Ł. et al. Plasma levels of IL-17, VEGF, and adrenomedullin and S-cone dysfunction of the retina in children and adolescents without signs of retinopathy and with varied duration of diabetes // Mediators Inflamm. – 2013. – Vol. 2013. – P. 274726.

49. Shimura M., Yasuda K., Nakazawa T. et al. Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy // Graefes Arch. Clin. Exp. Ophthalmol. – 2009. – Vol. 247, № 12. – P. 1617-1624.

50. Sonoda S., Sakamoto T., Yamashita T. et al. Retinal morphologic changes and concentrations of cytokines in eyes with diabetic macular edema // Retina. – 2014. – Vol. 34, № 4. – P. 741-748.

51. Suzuki Y., Nakazawa M., Suzuki K. et al. Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion // Jpn. J. Ophthalmol. – 2011. – Vol. 55. – P. 256-263.

52. Suzuki Y., Suzuki K., Yokoi Y. et al. Effects of intravitreal injection of bevacizumab on inflammatory cytokines in the vitreous with proliferative diabetic retinopathy // Retina. – 2014. – Vol. 34, № 1. – P. 165-171.

53. Van Geest R.J., Klaassen I., Vogels I.M. et al. Differential TGF-beta signaling in retinal vascular cells: a role in diabetic retinopathy? // Invest. Ophthalmol. Vis. Sci. – 2010. – Vol. 51, № 4. – Р. 1857-1865.

54. Wakabayashi Y., Usui Y., Okunuki Y. et al. Correlation of vascular endothelial growth factor with chemokines in the vitreous in diabetic retinopathy // Retina. – 2010. – Vol. 30. – P. 339-344.

55. Wakabayashi Y., Usui Y., Okunuki Y. et al. Increases of vitreous monocyte chemotactic protein 1 and interleukin 8 levels in patients with concurrent hypertension and diabetic retinopathy // Retina. – 2011. – Vol. 31. – P. 1951-1957.

56. Wakabayashi Y., Usui Y., Okunuki Y. et al. Intraocular VEGF level as a risk factor for postoperative complications after vitrectomy for proliferative diabetic retinopathy // Invest. Ophthalmol. Vis. Sci. – 2012. – Vol. 53, № 10. – P. 6403-6410.

57. Yoshida S., Kubo Y., Kobayashi Y. et al. Increased vitreous concentrations of MCP-1 and IL-6 after vitrectomy in patients with proliferative diabetic retinopathy: possible association with postoperative macular oedema // Br. J. Ophthalmol. – 2015. – Vol. 99, № 7. – Р. 960-966.

58. Yuuki T., Kanda T., Kimura Y. et al. Inflammatory cytokines in vitreous fluid and serum of patients with diabetic vitreoretinopathy // J. Diabetes Complications. – 2001. – Vol. 15, № 5. – Р. 257-259.

59. Zhou J., Wang S., Xia X. Role of intravitreal inflammatory cytokines and angiogenic factors in proliferative diabetic retinopathy // Curr. Eye Res. – 2012. Vol. 37, № 5. – P. 416-420.


Для цитирования:


Трунов А.Н., Черных Д.В., Еремина А.В., Черных В.В. ЦИТОКИНЫ И ФАКТОРЫ РОСТА В ПАТОГЕНЕЗЕ ПРОЛИФЕРАТИВНОЙ ДИАБЕТИЧЕСКОЙ РЕТИНОПАТИИ. Офтальмохирургия. 2017;(1):93-97. https://doi.org/10.25276/0235-4160-2017-1-93-97

For citation:


Trunov A.N., Chernykh D.V., Eremina A.V., Chernykh V.V. WTH FACTORS IN THE PATHOGENESIS OF PROLIFERATIVE DIABETIC RETINOPATHY. Fyodorov Journal of Ophthalmic Surgery. 2017;(1):93-97. (In Russ.) https://doi.org/10.25276/0235-4160-2017-1-93-97

Просмотров: 178


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 0235-4160 (Print)
ISSN 2312-4970 (Online)